Proteomics: The Science of Functional and Structural Characterization of Proteins

Mario Sergio Palma
Guest Editor
Full Professor of Proteomics
Institute of Biosciences, UNESP
Rio Claro, SP, Brazil

“The Brazilian proteomics community is very active and productive, investigating a wide variety of subjects and reflecting the large biodiversity of Brazilian nature.”

Back to the Future with Proteins and Proteomics

Gilberto B. Domont
Emeritus Professor
Proteomics Unit, IQ- UFRJ
Rio de Janeiro, RJ, Brazil

“My entire scientific life was dedicated to having fun doing research with my students … and helping students to begin and develop their national and international careers.”

Is Proteomics Possible Without Mass Spectrometry?

Marcelo Valle de Sousa
Full Professor
Dept. of Cell Biology, UnB, Brasilia, DF, Brazil

“…materials science must be greatly exploited as a frontier of chemical and analytical chemistry knowledge, but commonly, and as expected, analytical chemists have been the protagonists.”

Mass Spectrometry-Based Proteomics to Understand Schizophrenia

Daniel Martins de Souza
Associate Professor of Biochemistry
Institute of Biology, Unicamp
Campinas, SP, Brazil

“Proteomics emerged in the post genomic era as an alternative toolbox ... In the case of schizophrenia, we can easily see that proteomics has opened roads that...”

Review: Multi-Omics: An Opportunity to Dive into Systems Biology

Emerson A. F. dos Santos, Elisa C. S. Cruz, Henrique C. Ribeiro, Luidy D. Barbosa, Flávia S. Zandonadi, Alessandra Sussulini

This review describes a workflow example regarding multi-omics data integration, indicating mathematical and computational tools in analysis pipelines that use various methods to perform a sequence of tasks, which would be able to describe biological processes within the systems biology context.

A Contribution to the Analytical Proteomics of Human Intestinal Mucus: Sampling, Sample Preparation, and Protein Identification Strategies

Paola A. G. Buitrago, Carlos A. G. Correa, Mario S. Osorio, Gonzalo T. Ocampo, Hector Henrique F. Koolen, Marco A Z. Arruda

Several analytical proteomics strategies are presented in this study, which contribute to the proteomic map of human intestinal mucus, enlarging knowledge of this important sample.

In Situ Proteomic Analysis of Glioblastoma Multiforme: A Translational Approach to Improve Prognostic/Diagnostic Routines

Anally R. S. Menegasso, Marcel Pratavieira, Lucilene D. dos Santos, Flávio O. Lima, Marcelo P. T. Moraes, Marco Antonio Zanini, Mario Sergio Palma

In order to evaluate the application of MALDI MSI to the study of Glioblastoma, some sections of formalin fixed paraffin embedded samples of GBM were submitted to classical immunohistochemistry, for defining the profile of molecular markers of GBM grade IV.